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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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Multiple sclerosis in Brazil: A systematic review.

C C F Vasconcelos¹, L C S Thuler², B C Rodrigues¹

¹Universidade Federal do Estado do Rio de Janeiro, Rua Mariz e Barros 775, Departamento de Neurologia-Tijuca, Rio de Janeiro, CEP: 20270-901, Brazil.

Clinical Neurology and Neurosurgery

|October 19, 2016

Summary

This study reviewed multiple sclerosis (MS) in Brazil, finding that the clinical profile aligns with high-prevalence areas. African ancestry emerged as a risk factor for early disability and progression in MS patients.

Keywords:

Brazilian profile Clinical course Multiple sclerosis Natural history Prognostic factors Systematic review

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Area of Science:

Neurology
Epidemiology

Background:

Limited nationwide data on multiple sclerosis (MS) natural history in Brazil.
Existing regional studies provide fragmented insights into MS in Brazil.

Purpose of the Study:

To systematically review and synthesize available data on multiple sclerosis (MS) in Brazil.
To consolidate information on the clinical and demographic profiles of MS patients in Brazil.

Main Methods:

Systematic literature review of Brazilian studies published between 1990 and 2012.
Searches conducted in PubMed, SciELO, and Lilacs databases.
Keywords included "Brazil" or "Brazilian" combined with terms related to MS clinical and demographic profiles.

Main Results:

Analysis of 45 pediatric and 1922 adult MS patients.
Median age at onset: 10 years (pediatric) and 32 years (adult).
Women were more affected; motor complaints and relapsing-remitting phenotype were most common.
Predictors of disability and progression included early relapses, older age, male gender, and African ancestry.

Conclusions:

The Brazilian MS profile resembles that of high-prevalence regions.
African ancestry is identified as a risk factor for early disability and progression in MS.
Factors influencing MS incidence in Brazil do not appear to alter clinical patterns or outcomes.