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Updated: Mar 13, 2026

Modeling Chemotherapy Resistant Leukemia In Vitro
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Modeling the chronic lymphocytic leukemia microenvironment in vitro.

Kyle Crassini1, Yandong Shen1, Stephen Mulligan1,2

  • 1a Northern Blood Research Centre , Kolling Institute of Medical Research, Royal North Shore Hospital , Sydney , Australia.

Leukemia & Lymphoma
|October 21, 2016
PubMed
Summary

Targeting chronic lymphocytic leukemia (CLL) cells within the protective tumor microenvironment is crucial for effective treatment. In vitro models mimicking these environments help evaluate new therapies for improved clinical efficacy.

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Area of Science:

  • Oncology
  • Hematology
  • Cancer Biology

Background:

  • The lymph node and bone marrow microenvironments foster chronic lymphocytic leukemia (CLL) cell growth and resistance.
  • Targeting leukemic cells within these protective niches is essential for successful CLL treatment.

Purpose of the Study:

  • To review in vitro models that replicate the CLL tumor microenvironment.
  • To explore how these models aid in understanding CLL biology and therapeutic agent efficacy.

Main Methods:

  • Literature review of in vitro models simulating the CLL tumor microenvironment.
  • Analysis of how these models mimic in vivo leukemic cell survival and proliferation.

Main Results:

  • Various in vitro models have been developed to mimic key aspects of the tumor microenvironment.
Keywords:
Chronic lymphocytic leukemiadrug resistancemicroenvironment

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  • These models facilitate the study of CLL cell-stromal interactions and drug resistance mechanisms.

    • Conclusions:

    • In vitro models are valuable tools for pre-clinical evaluation of novel therapeutic agents in CLL.
    • Understanding microenvironmental interactions improves the prediction of clinical efficacy for new treatments.