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Pharmacokinetics of intravenous buprenorphine in children
K T Olkkola1, E L Maunuksela, R Korpela
1Department of Clinical Pharmacology, University of Helsinki, Finland.
British Journal of Clinical Pharmacology
|August 1, 1989
Abstract:
Buprenorphine (3 micrograms kg-1) was given intravenously as premedication to small children (age 4-7 years) undergoing minor surgery. Because of the rapid decline of the plasma buprenorphine concentrations, the terminal elimination half-life could not be estimated reliably. Given this constraint, values of clearance appeared to be higher than those in adults but values of Vss were similar.