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Updated: Jun 16, 2026
2-Methacryloyloxyethyl Phosphorylcholine Polymer Treatment of Complete Dentures to Inhibit Denture Plaque Deposition
Published on: December 26, 2016
Study protocol for a multi-center, randomized controlled trial to develop Japanese denture adhesive guidelines for
Suguru Kimoto1,2, Yasuhiko Kawai3,4, Atsuko Gunji3,4
1The denture care society, Administration Office of Denture Care Society, Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine, 2-1-3 Tsurumi, Tsurumi-ku, Kanagawa, 230-8501, Japan. kimoto.suguru@nihon-u.ac.jp.
This study investigates the effectiveness of denture adhesives for improving denture retention and stability in Japanese users. Findings will help establish guidelines for optimal use of these dental products.
Area of Science:
- Dentistry
- Prosthodontics
- Clinical Trials
Background:
- Denture adhesives are recognized medical products that enhance denture retention and stability.
- Japanese dentists exhibit reluctance in adopting denture adhesives due to a misconception that dentures should be inherently stable.
- This study aims to address this gap by verifying the efficacy of denture adhesives in the Japanese population.
Purpose of the Study:
- To verify the efficacy of denture adhesives (cream and powder types) in improving denture retention and stability.
- To establish evidence-based guidelines for the use of denture adhesives among Japanese denture wearers.
- To challenge the existing stereotype regarding the inherent stability of dentures.
Main Methods:
- A ten-center, randomized controlled trial involving 300 edentulous patients with complete dentures.
- Participants are allocated to three groups: cream-type adhesive, powder-type adhesive, and a control (saline solution).
- Outcomes measured include general and functional denture satisfaction, bite force, dislodgement resistance, masticatory performance, and quality of life, assessed over four days.
Main Results:
- The study is ongoing, and results are pending.
- Statistical analysis will include between-subjects and within-subjects comparisons, as well as multiple regression analysis.
- The intention-to-treat principle will guide the main analyses, with a planned sample size of 100 subjects per group.
Conclusions:
- This clinical trial will provide crucial data on denture adhesive efficacy for Japanese complete denture wearers, educators, and dentists.
- The findings are expected to influence clinical practice in Japan and potentially other countries.
- Evidence generated will support the integration of denture adhesives into routine dental care.
