Cholinergic pruritus, erythema and urticaria: a disease spectrum responding to danazol

Cholinergic pruritus and cholinergic erythema are relatively rare conditions believed to represent variants of cholinergic urticaria. We report an extremely severe and unusual case demonstrating features of both these variants before evolving into more classical cholinergic urticaria. This strongly supports the view that all three syndromes are variations of the same disease. This case demonstrated a dramatic symptomatic response to danazol which has not previously been reported.