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HIV and aging.

Edward J Wing1

  • 1The Miriam Hospital, Brown University, 164 Summit Avenue, Providence, RI 02906, USA.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|October 21, 2016
PubMed
Summary
This summary is machine-generated.

The global human immunodeficiency virus (HIV) population is aging, with over 10% now over 50. Managing aging HIV patients requires early diagnosis, comorbidity prevention, and addressing quality of life.

Keywords:
AgingAntiretroviralCo-morbiditiesHIVInflammation

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Area of Science:

  • Gerontology
  • Infectious Diseases
  • Public Health

Background:

  • The global human immunodeficiency virus (HIV) population is aging due to increased life expectancy with antiretroviral therapy.
  • Over 10% of the 34.5 million HIV-positive individuals worldwide are over 50, a proportion projected to rise significantly.
  • While life expectancy has improved, it remains lower than in HIV-negative individuals, and the impact of HIV on aging is debated.

Purpose of the Study:

  • To highlight the growing demographic of aging HIV patients.
  • To discuss the associated health challenges, including accelerated aging and comorbidities.
  • To outline key management strategies for this population.

Main Methods:

  • Literature review and synthesis of current epidemiological data on aging with HIV.
  • Analysis of the impact of chronic inflammation on age-related diseases in HIV.
  • Examination of best practices in managing comorbidities and polypharmacy.

Main Results:

  • Aging HIV patients face higher rates of cardiovascular, renal, neurocognitive, oncological, and osteoporotic diseases.
  • Geriatric syndromes, such as frailty, are more prevalent in this population.
  • Chronic inflammation persists even with suppressed viral loads, contributing to disease burden.

Conclusions:

  • Effective management necessitates early diagnosis, proactive comorbidity prevention, and judicious medication use.
  • Addressing quality of life, medical priorities, and end-of-life care is crucial for older adults with HIV.
  • The aging HIV population presents unique challenges requiring tailored healthcare approaches.