Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Understanding Sleep01:11

Understanding Sleep

1.8K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.8K
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

770
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
770
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

509
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
509
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

1.9K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.9K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

3.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.2K
Management of Insomnia01:19

Management of Insomnia

758
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
758

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anxiety, for better or for worse.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Cumulative traumatic brain injury as a predictor of Parkinson's disease with sex-related differences.

Parkinsonism & related disorders·2026
Same author

Levodopa-Induced dyskinesia in Latin America: Prevalence and associated clinical factors in the LARGE-PD cohort.

Journal of Parkinson's disease·2026
Same author

Age-Dependent Differences in Cerebellar CB1 Receptor Expression and Its Association With Impulsivity and Alcohol Intake in Rats.

Addiction biology·2025
Same author

The Effect of Attentional Locus on Multisensory Congruence: An ERP Study.

Psychophysiology·2025
Same author

The CB1 receptor: linking impulsivity and substance use disorder.

Frontiers in neuroscience·2025

Related Experiment Video

Updated: Mar 13, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.6K

Endocannabinoids and sleep.

Oscar Prospéro-García1, Octavio Amancio-Belmont1, Alline L Becerril Meléndez1

  • 1Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico.

Neuroscience and Biobehavioral Reviews
|November 7, 2016
PubMed
Summary
This summary is machine-generated.

Endocannabinoids (eCBs) and N-acylethanolamides (NAEs) are endogenous lipids that modulate sleep. eCBs promote sleep, while NAEs promote wakefulness, influencing the sleep-wake cycle.

Keywords:
2-AGAnandamideCannabinoid systemOleamide N-acylethanolamidesSleep-waking cycle

More Related Videos

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

627
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K

Related Experiment Videos

Last Updated: Mar 13, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
08:45

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

25.6K
Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
03:43

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

Published on: August 22, 2025

627
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

6.2K

Area of Science:

  • Neuroscience
  • Sleep Science
  • Endocrinology

Background:

  • Sleep is regulated by complex interactions within the brain.
  • Endocannabinoids (eCBs) and N-acylethanolamides (NAEs) are endogenous lipid signaling molecules with diverse physiological roles.
  • Both eCBs and NAEs have been implicated in the regulation of the sleep-wake cycle.

Purpose of the Study:

  • To analyze existing literature on the role of eCBs and NAEs in sleep regulation.
  • To determine if eCBs and NAEs function as sleep modulators.
  • To synthesize experimental evidence regarding the specific effects of eCBs and NAEs on sleep architecture.

Main Methods:

  • Literature review and analysis of experimental studies.
  • Examination of the circadian control of eCBs and NAEs.
  • Investigation of the effects of eCBs and NAEs on sleep and wakefulness.

Main Results:

  • Evidence suggests eCBs and NAEs exhibit circadian rhythmicity.
  • NAEs promote wakefulness.
  • eCBs promote both non-rapid-eye movement and rapid-eye-movement sleep, partly through interaction with melanin-concentrating hormone neurons.
  • Blockade of cannabinoid receptor 1 (CB1R) increases wakefulness and reduces sleep.
  • eCBs demonstrated efficacy in restoring sleep in an animal model of insomnia.

Conclusions:

  • eCBs and NAEs are significant modulators of the sleep-wake cycle.
  • eCBs primarily promote sleep, while NAEs promote wakefulness.
  • Targeting the eCB system, particularly CB1R, holds potential for therapeutic interventions in sleep disorders like insomnia.