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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:46

Epigenetic Regulation

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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
38.5K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.8K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.8K
Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Mar 13, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

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The Epigenetics of Normal Pregnancy.

Jonathan D Best1, Nessa Carey1

  • 1CellCentric, Chesterford Research Park, Little Chesterford CB10 1XL, UK.

Obstetric Medicine
|March 1, 2013
PubMed
Summary

Epigenetic regulation is crucial for fetal development and cell fate. This review highlights its role in prenatal development and the pregnant woman, addressing a gap in current research.

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Genomics

Background:

  • Epigenetic modifications regulate cell fate and gene expression in response to environmental cues.
  • Epigenetics plays a vital role in fetal development and prenatal programming.
  • Limited research exists on epigenetic changes in pregnant women.

Approach:

  • This review synthesizes current understanding of epigenetic regulation in the prenatal phase.
  • It addresses the intersection of fetal health and epigenetics.
  • The review also examines the under-discussed role of maternal epigenetics.

Key Points:

  • Epigenetic mechanisms are essential for cell fate determination and response to stimuli.
  • Prenatal epigenetic regulation is critical for healthy fetal development.
Keywords:
endocrinologymetabolismnutritionphysiology

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  • Maternal epigenetic modifications during pregnancy warrant further investigation.

    • Conclusions:

    • Epigenetics is fundamental to prenatal development and maternal health.
    • Further research is needed to elucidate the role of maternal epigenetics in pregnancy outcomes.
    • Understanding these epigenetic processes can inform interventions for fetal and maternal well-being.