Related Experiment Video
Updated: Sep 3, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
Published on: January 17, 2011
Caustic Ingestion in Children: a Systematic Review and Meta-Analysis
Mandana Rafeey1, Morteza Ghojazadeh2, Saeede Sheikhi3
1Department of Pediatrics Gastroenterology, Medicine Faculty, Liver & Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Insights
Accidental caustic ingestion is a common pediatric issue, often involving household cleaners. This preventable problem requires coordinated efforts from families, health professionals, and media for effective management and prevention.
Area of Science:
- Pediatric Toxicology
- Public Health
- Gastroenterology
Background:
- Accidental caustic ingestion is a significant health concern in children.
- Household cleaning products are frequently involved in these incidents.
Purpose of the Study:
- To systematically review the literature on pediatric caustic ingestion.
- To identify common substances, risk factors, and outcomes associated with caustic ingestion in children.
Main Methods:
- Systematic review of articles from Science Direct, ProQuest, Google Scholar, and PubMed.
- Keywords: caustic, corrosive, ingestion, children. Limited to English and Persian articles.
- Data analysis using Comprehensive Meta-Analysis2 and PASW Statistics 18.
Main Results:
- Analyzed 64 articles with 11,345 cases of pediatric caustic ingestion.
- Higher incidence observed in young boys; common agents include household cleaners (bleaches, cleaners).
- Reported complications include esophageal cancer, death, and digestive/respiratory issues; diagnosis and treatment are often invasive and costly.
Conclusions:
- Pediatric caustic ingestion is a serious but preventable and manageable issue.
- Multifaceted efforts involving families, government, industry, healthcare teams, and media are crucial for adequate management and prevention.
Abstract:
Caustic ingestion that occurs accidently is one of the most common problems in children. This systematic review has been performed by searching the databases including Science Direct, ProQuest, Google Scholar, and PubMed. A strategic search was performed with keywords including caustic, corrosive, ingestion, and children, and was limited to articles in English and Persian. Data were analyzed using Comprehensive Meta-Analysis2 and PASW Statistics 18. We selected 64 articles regarding caustic ingestion with a total sample of 11,345 cases. The data analysis indicated a higher consumption in young boys (age range 2.78 (2.02) years (OR=0.53 with a 95% confidence interval of 0.49-0.57 (P=0.08)). The most common caustic substances were household cleaning agents, particularly bleaches and cleaners. Esophageal cancer and death were reported as well as digestive and respiratory complications. Invasive and expensive techniques are frequently used for diagnosis, treatment and follow up. The results demonstrated that although caustic ingestion is a serious problem among children, it is a preventable and manageable issue. Therefore, appropriate efforts by families, government, factories, health team and media should be made to handle adequately this matter.
Related Concept Videos
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Prevention of Further Absorption of Poison
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Pharmaceutical Poisoning: Treatment Strategies

