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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Classification of Follow-up Rehabilitation ("AHB") in the Context of Postoperative Cochlear Implant (CI) Care.

Laryngo- rhino- otologie·2025
Same author

Recommendations for selection of target parameters and process recommendations for audiological and technical functional testing of cochlear implant : Prepared by the ERA consortium (AG-ERA) of ADANO in cooperation with the Implantable Hearing Systems expert committee of the DGA. Confirmed by the board of ADANO on 31.01.2025.

HNO·2025
Same author

[Recommendations for selection of target parameters and process recommendations for audiological and technical functional testing of cochlear implant : Prepared by the ERA consortium (AG-ERA) of ADANO in cooperation with the Implantable Hearing Systems expert committee of the DGA. Confirmed by the board of ADANO on 31.01.2025. German version].

HNO·2025
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[Negative pressure in the ear canal with consequences].

HNO·2024
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The German cochlear implant registry: one year experience and first results on demographic data.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024
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[The WHO grades of hearing loss : A consensus on the German version].

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Related Experiment Video

Updated: Mar 13, 2026

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

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[Intracochlear drug delivery in combination with cochlear implants : Current aspects].

S K Plontke1, G Götze2, T Rahne2

  • 1Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Hals-Chirurgie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland. stefan.plontke@uk-halle.de.

HNO
|November 6, 2016
PubMed
Summary

Local drug delivery to the inner ear improves cochlear implant (CI) function. A biocompatible system releasing dexamethasone successfully treated CI patients with hearing loss and impedance issues.

Keywords:
CochleaCochlear implantDrug therapyImpedanceInner ear

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Area of Science:

  • Otic drug delivery systems
  • Biocompatible materials for inner ear applications
  • Cochlear implant technology integration

Background:

  • Systemic drug delivery to the inner ear presents challenges.
  • Local drug application offers advantages for inner ear conditions.
  • Cochlear implants (CI) can be enhanced with drug-releasing electrode carriers.

Observation:

  • Drug-eluting electrodes aim to protect neural structures and reduce fibrosis.
  • Biocompatible, resorbable drug delivery systems facilitate controlled release.
  • Two cases demonstrate successful treatment of CI patients with dexamethasone via intracochlear placement.

Findings:

  • Intracochlear dexamethasone delivery improved speech discrimination and reduced impedance in CI patients.
  • Computer models can predict inner ear drug concentrations for various application strategies.
  • Calculated intracochlear drug levels were compared across different dexamethasone application methods.

Implications:

  • Local drug delivery holds promise for improving CI rehabilitation outcomes.
  • Controlled release systems can mitigate insertion trauma and promote neural growth.
  • Further research into drug delivery strategies can optimize CI performance and patient recovery.