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Interim evaluation of efficacy or futility in group-sequential trials with multiple co-primary endpoints

Koko Asakura1,2, Toshimitsu Hamasaki1,2, Scott R Evans3

  • 1Department of Data Science, National Cerebral and Cardiovascular Center, Suita, Osaka, 565-8565, Japan.

Biometrical Journal. Biometrische Zeitschrift
|October 21, 2016
PubMed

Keywords:
Error-spending methodFutilityMultiple endpointsNonbinding boundaryType I and Type II error adjustments

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