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Loss of Eyebrows and Eyelashes During Concomitant Treatment with Sitagliptin and Metformin
Elena Succurro, Caterina Palleria, Mariafrancesca Ruffo
1Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, Mater Domini University Hospital, Viale Europa - Germaneto, 88100 Catanzaro,. Italy.
Abstract:
The fixed dose combination of sitagliptin 50 mg and metformin 850 mg (Janumet ®), is indicated for the treatment of type 2 diabetes mellitus in addition to diet and exercise to improve glycemic control in patients treated with metformin alone.
Methods:
We report a 69-year-old man with type 2 diabetes that developed sudden loss of eyebrows and eyelashes about 4 months after the beginning of Janumet®. Clinical and laboratory findings excluded the presence of systemic or skin diseases able to induce these manifestations, while the Naranjo probability scale documented a possible association between the drug and the adverse drug reaction.
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