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[Towards new targets in the treatment of hypertension?]

Anne-Laure Faucon1, Anne-Marie Madjalian1, Guillaume Bobrie1

  • 1Unité d'hypertension artérielle, Hôpital Européen Georges Pompidou, AP-HP, 20, rue Leblanc, 75015 Paris Paris, France ; Centre d'investigation clinique (CIC 1418), Hôpital Européen Georges Pompidou, AP-HP, Paris, 20, rue Leblanc, 75015 Paris France ; Université Paris-Descartes, Paris, France.

Medecine Sciences : M/S
|October 21, 2016
PubMed

Insights

Blood pressure targets for antihypertensive therapy are debated. The SPRINT study

Area of Science:

  • Cardiology
  • Public Health

Background:

  • Blood pressure is a key factor in cardiovascular disease risk.
  • Antihypertensive therapy targets and applicable populations remain subjects of ongoing scientific debate.
  • The 2015 Systolic Blood Pressure Intervention Trial (SPRINT) study has influenced current blood pressure management guidelines.

Purpose of the Study:

  • To evaluate the generalizability of the SPRINT study findings to the French population.
  • To assess the implications of applying SPRINT-like blood pressure targets in France.

Main Methods:

  • Analysis of the SPRINT study results.
  • Comparative risk assessment between US and French populations.
  • Evaluation of potential medical and economic consequences.

Main Results:

  • The SPRINT study results may not be directly applicable to the French population.
  • The French population exhibits a lower cardiovascular risk profile compared to the US population studied in SPRINT.
  • Direct application of SPRINT targets could lead to significant medical and economic challenges in France.

Conclusions:

  • Current blood pressure management guidelines may require adaptation for the French population.
  • Lowering blood pressure targets based on SPRINT may not be appropriate or cost-effective for France.
  • Further research is needed to establish optimal, population-specific blood pressure targets.

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