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Updated: Mar 13, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Neuroinflammatory and morphological changes in late-life depression: the NIMROD study
L Su1, Y O Faluyi2, Y T Hong2
1Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, UK; Silvy Gabel, MSc, Department of Psychiatry, University of Cambridge, UK and Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands; Lawrence Hayes, MBBS, Soteris Soteriades, BA, Department of Psychiatry, University of Cambridge, UK; Guy B. Williams, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Robert Arnold, BSc, Department of Psychiatry, University of Cambridge, UK; Luca Passamonti, MD, Patricia Vázquez Rodríguez, MSc, Department of Clinical Neurosciences, University of Cambridge, UK, Ajenthan Surendranathan, MRCP, Richard W. Bevan-Jones, MBBChir, Department of Psychiatry, University of Cambridge, UK; Jonathan Coles, PhD, Division of Anaesthesia, Department of Medicine, University of Cambridge, UK; Franklin Aigbirhio, DPhil, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; James B. Rowe, PhD, Department of Clinical Neurosciences, University of Cambridge and Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK; John T. O'Brien, DM, Department of Psychiatry, University of Cambridge, UK ls514@cam.ac.uk.
None:
We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
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