Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates
Sawsan Mahmoud1,2, Hao Li1, Tamara R McBrayer3
1a Center for AIDS Research , Laboratory of Biochemical Pharmacology , Department of Pediatrics , Emory University School of Medicine , Atlanta , Georgia , USA.
Nucleosides, Nucleotides & Nucleic Acids
|October 21, 2016
Abstract:
A novel series of tetrafluoro and hexafluoro acyclic nucleosides and their phosphoramidates were successfully prepared from commercially available 2,2,3,3-tetrafluoro-1,4-butanediol and 2,2,3,3,4,4-hexafluoro-1,5-pentanediol in four to six steps. Their ability to block HIV, HCV, HSV-1, and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM, and Vero cells was assessed.
