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Pilar Bueno Vargas1, Manuel Manzano Martín, Inmaculada López-Aliaga

  • 1Abbott Nutrition R&D. Granada. Departamento de Fisiología. Facultad de Farmacia. Universidad de Granada e Instituto de Nutrición y Tecnología de los Alimentos "José Mataix". Universidad de Granada. Granada. pilar.bueno@abbott.com.

Nutricion Hospitalaria
|October 21, 2016
PubMed
Summary

Maternal bone density (BMD) can decrease during pregnancy and lactation. Supplementing with inulin-oligofructose prebiotic fiber protected maternal bone mass in rats, suggesting a nutritional strategy for perinatal bone health.

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Area of Science:

  • Nutritional Science
  • Bone Metabolism
  • Reproductive Physiology

Background:

  • Pregnancy and lactation are associated with temporary maternal bone mineral density (BMD) loss.
  • Calcium supplementation may mitigate skeletal bone mass reduction.
  • Prebiotics can enhance mineral absorption, influencing bone mineralization.

Purpose of the Study:

  • To investigate the effect of inulin-enriched with oligofructose prebiotic supplementation during gestation and lactation on maternal bone mineral content (BMC) and BMD.
  • To assess the impact on bone health at the end of the lactation period.

Main Methods:

  • Gestating rats were assigned to standard diet (CC), calcium-fortified diet (Ca), or prebiotic-enriched diet (Pre).
  • Bone mineral content (BMC) and BMD were evaluated using dual-energy X-ray absorptiometry (DEXA).
Keywords:
Gestación. Lactación. Prebióticos. Calcio. Densidad ósea.

Related Experiment Videos

  • Cecal content pH was measured.

    • Main Results:

    • The prebiotic group (Pre) exhibited the highest absolute BMC and BMD values overall.
    • Tibia BMC and BMD were significantly higher in the CC and Pre groups compared to the Ca group.
    • Cecal content pH was significantly lower in the Pre group than in the CC and Ca groups.

    Conclusions:

    • Inulin-enriched with oligofructose supplementation, under non-calcium-deficient conditions, protects the maternal skeleton in rats.
    • This prebiotic can be considered a nutritional strategy to preserve maternal bone mass during the perinatal period.