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Updated: Mar 13, 2026
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Relationship between visual field changes and optical coherence tomography measurements in advanced open-angle
Snezhina S Kostianeva1,2, Marieta I Konareva-Kostianeva1,2, Marin A Atanassov1,2
1Department of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria
Folia Medica
|October 21, 2016
Summary
Nonlinear regression models better assess functional and structural changes in advanced open-angle glaucoma (OAG). Moderate correlations were found between visual field indices and spectral-domain optical coherence tomography (SD-OCT) measurements.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Advanced open-angle glaucoma (OAG) involves progressive visual field loss.
- Spectral-domain optical coherence tomography (SD-OCT) enables detailed structural analysis of the retina.
- Understanding the relationship between functional and structural changes is crucial for OAG management.
Purpose of the Study:
- To evaluate the correlation between visual field deficits and retinal structural measurements in OAG patients.
- To determine the most appropriate regression models for analyzing these relationships.
Main Methods:
- Included 31 eyes from 25 patients with advanced OAG.
- Utilized standard automated perimetry (SAP) for visual field assessment.
- Employed SD-OCT for quantitative retinal structural measurements.
Main Results:
- Moderate correlations (r between 0.3-0.6) were observed between visual field indices (MD/PSD) and most OCT measurements.
- Nonlinear cubic regression showed a significant correlation between mean deviation (MD) and ganglion cell complex (GCC) (R2=0.417, P=0.004).
- Good correlation found between MD and global layer volume (GLV) (R2=0.383, P=0.008).
Conclusions:
- Nonlinear regression models are more suitable for assessing functional and structural changes in advanced glaucoma.
- The study identified moderate correlations, highlighting the complexity of glaucoma progression.
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