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Experts Opinion on the Practical Use of Azathioprine and 6-Mercaptopurine in Inflammatory Bowel Disease
Christian Mottet1, Alain M Schoepfer, Pascal Juillerat
1*Division of Gastroenterology, Hôpital Neuchâtelois, Neuchâtel, Switzerland;†Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;‡Division of Gastroenterology Clinic for Visceral Surgery and Medicine, Inselspital Bern, Bern, Switzerland;§Division of Gastroenterology and Hepxatology, Saint-Antoine Hospital, Pierre et Marie Curie-Paris 6 University, Paris, France;‖Division of Gastroenterology, University Hospital of Basel, Basel, Switzerland;¶Division of Gastroenterology and Hepatology, Ospedale Regionale di Lugano, Lugano, Switzerland;**Division of Gastroenterology and Hepatology, Lindenhofspital Bern, Bern, Switzerland;††Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland;‡‡Division of Gastroenterology and Hepatology, Stadtspital Triemli, Zurich, Switzerland; and§§Crohn and Colitis Centre, Clinique La Source-Beaulieu, Lausanne, Switzerland.
Abstract:
The relevance of azathioprine and 6-mercaptopurine therapy in inflammatory bowel disease, Crohn's disease, and ulcerative colitis, has been challenged in recent publications. In this article, a panel of experts gives advice, based on the relevant literature, on indications and practical use of azathioprine/6-mercaptopurine, prevention, and management of drug adverse reactions and special situations such as vaccination, pregnancy, and lactation.
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