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Class II-Restricted CD8s: New Lessons Violate Old Paradigms

Stephen A Migueles1, Mark Connors1

  • 1HIV-Specific Immunity Section, Laboratory of Immunoregulation, Division of Intramural Research NIAID, Bethesda, MD 20892, USA.

Immunity
|October 21, 2016
PubMed

CD8+ T cells that recognize peptides presented by MHC class II molecules have been observed in a macaque SIV vaccine model. A new study by Ranasinghe et al. (2016) shows that virus-specific class-II-restricted CD8+ T cells can be found in some HIV-infected patients.

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