[Pituitary changes under CT scan before and after replacement therapy in patients with primary hypothyroidism]

Pituitary enlargement was detected on CT scanning in 10 of 17 patients with primary hypothyroidism before thyroid hormone replacement therapy. The serum prolactin levels were slightly elevated in patients with pituitary enlargement. After replacement therapy with thyroid tablet, the enlarged pituitary glands were returned to normal in 6 patients when they were in euthyroid, while another patient's pituitary was still enlarged for inadequate dose of thyroid tablet. In conclusion, pituitary enlargement was frequently seen in patients with primary hypothyroidism and can be restored to normal after effective treatment with thyroid hormones.