[Changes of mucosal blood flow in the healing process of peptic ulcer]

Changes of gastroduodenal mucosal blood flow (GDMBF) in the healing process of 79 cases of gastric ulcer and 118 cases of duodenal ulcer were investigated by Laser Doppler Flowmetry during endoscopy. 108 cases with no gastroduodenal lesions were used as controls. In the controls, the mucosal blood flow was greater at the corpus than at the antrum and the angle, and it was smaller at the lesser curvature than at the greater curvature. The mucosal blood flow at the antrum and the angle of the lesser curvature was the smallest. The mucosal blood flow at the anterior wall of the duodenal bulbus was lower than at the lesser curvature and the posterior wall. In patients with active gastric ulcer, GMBF were decreased significantly. The mucosal blood flow at the ulcer center and ulcer margin was lower in the active stage and it was increased markedly in the healing stage, while no marked change was observed in peripheral mucosal blood flow during the different stages.