Related Experiment Video

Updated: Mar 13, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

11.1K

Synergistic effect of anidulafungin combined with posaconazole in experimental aspergillosis

Adela Martin-Vicente, Javier Capilla, Josep Guarro

    Medical Mycology
    |October 21, 2016
    PubMed

    Insights

    The combination of anidulafungin and posaconazole demonstrated efficacy against Aspergillus fumigatus infections in mice, improving survival and reducing fungal burden. This antifungal combination therapy shows promise for treating difficult-to-treat invasive fungal infections.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Discrepancies exist regarding the efficacy of combined antifungal therapies, specifically triazoles and echinocandins.
    • Aspergillus fumigatus poses a significant threat, causing invasive infections, particularly in immunocompromised individuals.

    Purpose of the Study:

    • To evaluate the efficacy of anidulafungin plus posaconazole combination therapy against a murine systemic infection model caused by Aspergillus fumigatus.
    • To compare the combination therapy's effectiveness against monotherapies and voriconazole.

    Main Methods:

    • A murine model of systemic Aspergillus fumigatus infection was utilized.
    • Survival rates and fungal burden in kidneys were assessed.
    • In vitro-in vivo correlation was established using a synergy cutoff value.

    Main Results:

    • The anidulafungin-posaconazole combination significantly increased mouse survival compared to monotherapies and voriconazole.
    • A substantial reduction in kidney fungal burden was observed.
    • Kidney clearance ranged from 62% to 100%, depending on the fungal strain.
    • A good in vitro-in vivo correlation was noted, with a cutoff < 1 indicating synergy.

    Conclusions:

    • Anidulafungin plus posaconazole exhibits significant therapeutic potential against systemic Aspergillus fumigatus infections in mice.
    • This combination therapy could be a valuable option for treating infections refractory to standard antifungal treatments.
    • The findings support further investigation into this combination for clinical application in invasive aspergillosis.
    Keywords:
    A. fumigatusanidulafungincombined therapymurine modelposaconazole

    More Related Videos

    High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method07:51

    High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

    Published on: May 21, 2018

    12.8K
    Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells09:27

    Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells

    Published on: April 2, 2021

    4.5K

    Related Concept Videos

    Combined Effects of Drugs: Synergism01:27

    Combined Effects of Drugs: Synergism

    Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
    Such synergistic combinations...
    7.1K
    Combined Effects of Drugs: Antagonism01:30

    Combined Effects of Drugs: Antagonism

    The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
    The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
    12.0K
    Drug toxicity: Drug–Drug Interaction01:30

    Drug toxicity: Drug–Drug Interaction

    Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
    223
    Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

    Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

    PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
    59
    Fungal Phylum Ascomycota01:28

    Fungal Phylum Ascomycota

    Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
    2.2K