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Evaluation of Serum S100A8/S100A9 Levels in Patients with Autoimmune Thyroid Diseases
Hakan Korkmaz1, Suzan Tabur2, Esen Savaş3
1Department of Endocrinology and Metabolic Disease, Edirne State Hospital, Edirne, Turkey.
Background:
The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD).
Aims:
We aimed to evaluate the level of serum S100A8/S100A9 in AITD.
Study Design:
Case control study.
Methods:
Fifty patients with AITD (25 Hashimoto's thyroiditis (HT) and 25 Graves' disease (GD)) were included in the study. Twenty seven healthy subjects participated as a control group. Blood samples were obtained in the 3 months after the initiation of medical treatment. Serum levels of total antioxidant status (TAS), total oxidative status (TOS), total free sulfhydryl (SH), lipid hydroperoxide (LOOH) and S100A8/S100A9 were analyzed.
Results:
The patients with AITD had significantly higher S100A8/S100A9, OSI, LOOH and TOS levels than the healthy control group. There was no significant difference between GD and HT patients in terms of S100A8/S100A9, TOS and OSI levels. S100A8/S100A9 level was positively correlated with LOOH, TOS and OSI levels but negatively correlated with -SH level in the patients with AITD.
Conclusion:
Serum S100A8/S100A9 levels were increased in patients with AITD and positively correlated with LOOH, TOS and OSI whereas negatively correlated with SH.
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