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Updated: Mar 13, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
Published on: August 1, 2017
The role of hematopoietic stem cell niche in prostate cancer bone metastasis
A M Decker1, Y Jung1, F Cackowski2
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, USA.
Abstract:
Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to prostate cancer cell homing and dormancy in the bone marrow. This review also discusses the role of DTCs in the niche environment and discusses the role of erythropoietin in targeting DTCs within the HSC niche.
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