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Models of Bone Metastasis
Published on: September 4, 2012
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The role of extracellular calcium in bone metastasis
Ines Breuksch1, Maria Weinert1, Walburgis Brenner1
1Dept. of Gynecology/Urology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.
Journal of Bone Oncology
|October 21, 2016
Abstract:
This review summarizes the role of extracellular calcium, as found present in the bone tissue, in the process of bone metastasis.
Keywords:
AKT, AKT8 virus oncogene cellular homologBMP's, bone morphogenetic proteinsBone metastasisCOPD, chronic obstructive pulmonary diseaseCaSRCaSR, calcium-sensing receptorCalciumERK, extracellular signal-regulated kinaseET-1, endothelin-1FGF, fibroblast growth factorIGF, insulin-like growth factorIon channelsJNK, jun N-terminal kinaseM-CSF, macrophage colony-stimulating factorMAPK, mitogen-activated protein kinasePDGF, platelet-derived growth factorPGE-2, prostaglandin E-2PKA, protein kinase APLC, phospholipase CPSA, prostate specific antigenPTEN, phosphatase and tensin homolog deleted on chromosome 10PTHrP, parathyroid hormone-related proteinRANK, receptor activator of NF-κBRANKL, receptor activator of NF-κB ligandSK3, small conductance calcium-activated potassium channel 3TGFβ, transforming growth factor betaTRP, transient receptor potentialcAMP, cyclic adenosine monophosphateMore Related Videos
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