Melanotic neuroectodermal tumour of infancy - A rare entity

Area of Science:

• Pediatric Oncology
• Oral Pathology
• Developmental Biology

Background:

• Melanotic neuroectodermal tumour of infancy (MNTI) is a rare, rapidly growing, pigmented neoplasm of neural crest origin.
• While generally benign, MNTI exhibits rapid and locally destructive growth, primarily affecting the infant maxilla within the first year of life.
• Recurrence rates range from 10-15%, with malignant transformation reported in 6.5% of cases.

Purpose of the Study:

• To report a rare case of MNTI in a 5-month-old male infant.
• To describe the clinical, radiographic, and histologic features of MNTI.
• To discuss the surgical management and follow-up of this rare condition.

Main Methods:

• Case report of a 5-month-old male infant diagnosed with MNTI.
• Clinical, radiographic, and histopathological evaluation of the tumor.
• Surgical excision and post-operative follow-up.

Main Results:

• The MNTI case was associated with an erupted primary tooth.
• Detailed clinical, radiographic, and histologic findings were documented.
• Surgical management and follow-up were performed.

Conclusions:

• MNTI is a rare but significant condition in infants, requiring careful management.
• Early diagnosis and surgical intervention are crucial for favorable outcomes.
• Continued follow-up is necessary to monitor for recurrence or malignant changes.