Biokinetic datasets of PEI F25-LMW complexed and non-complexed 32P-siRNA within different lung compartments
Jens Lipka1, Manuela Semmler-Behnke2, Alexander Wenk2
1Comprehensive Pneumology Center Institute of Lung Biology and Disease, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany; Philipps-University of Marburg Department of Pharmaceutics and Biopharmacy, Ketzerbach 63, 35037 Marburg, Germany.
Abstract:
Biokinetics data of lung-administered PEI F25-LMW/siRNA polyplexes within different lung compartments are presented. Thereby, at three different timepoints (1 h, 3 h, 8 h), the data was determined by calculations to the 32P-radioactivity in the whole mouse body. Additionally, data was optimized to the available PEI F25-LMW/siRNA polyplexes in the target organ and therefore normalized to the sum of all lung compartments. Methods, other biokinetics data and the discussion of the results are published in "Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice" (Lipka et al., 2016 [1]).
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