[Interactions of drugs with PHEMA hydrogel]

Hydration of polyhydroxyethylmethacrylate (PHEMAs hydrogel with aqueous solutions of medicinal substance) renders it possible to deposit medicinal substances within the hydrogel. At the same time the concentration of the medicinal substances in the hydrogel is higher than their concentration in the hydrating solution. For the nonspecific interactions, which affect the deposition of medicinal substances in hydrogel, their surface tension is of principal importance. With decreasing surface tension the amount of medicinal substances in hydrogel is increased and simultaneously their release into the aqueous medium is decelerated. Interactions of six selected medicinal substances with PHEMA hydrogel were experimentally checked in the in vitro conditions.