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Microcomputer programs for complex epidemiologic procedures. I. Computation of adjusted rates.

M H Dong1

  • 1Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20857.

Computers and Biomedical Research, an International Journal
|August 1, 1989
PubMed
Summary
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Epidemiological cohort studies use excess rates to assess risk factor associations. A new microcomputer program simplifies calculating these adjusted excess rates, aiding dose-response analysis and causal inference.

Area of Science:

  • Epidemiology
  • Biostatistics

Background:

  • Excess rate is a key measure of association in epidemiological cohort studies.
  • Calculating excess rates adjusted for multiple confounders is crucial for dose-response analysis and causal inference.
  • Existing adjustment methods require complex iterative procedures, often necessitating computer assistance.

Purpose of the Study:

  • To present a microcomputer program for calculating adjusted excess rates.
  • To simplify the complex indirect standardization method for epidemiological research.

Main Methods:

  • The study describes an indirect method of standardization to compute excess rates.
  • The method adjusts for confounding effects of multiple risk factors using an iterative procedure.
  • A microcomputer program is provided to implement this calculation.

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Main Results:

  • The developed microcomputer program facilitates the computation of adjusted excess rates.
  • The program simplifies a previously laborious and complex statistical procedure.
  • The application of the program is illustrated in the communication.

Conclusions:

  • The microcomputer program makes adjusted excess rate computation accessible for epidemiological studies.
  • This tool aids in determining dose-response relationships and assessing causality.
  • The program supports researchers in handling complex confounding factors in cohort studies.