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BOOMER, a simulation and modeling program for pharmacokinetic and pharmacodynamic data analysis.

D W Bourne1

  • 1College of Pharmacy, University of Oklahoma, Oklahoma City 73190.

Computer Methods and Programs in Biomedicine
|July 1, 1989
PubMed
Summary

BOOMER is a versatile non-linear regression program that simplifies pharmacokinetic model definition. It offers flexible parameterization for differential and integrated equation models, enhancing usability for researchers.

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Area of Science:

  • Pharmacometrics
  • Non-linear Regression Analysis
  • Computational Biology

Background:

  • Traditional pharmacokinetic modeling often requires users to write FORTRAN subroutines.
  • Earlier programs like MULTI-FORTE provided a foundation for non-linear regression.
  • A need exists for more intuitive and flexible modeling software.

Purpose of the Study:

  • To introduce BOOMER, an enhanced non-linear regression program.
  • To provide a user-friendly interface for defining complex pharmacokinetic models.
  • To offer flexibility in specifying differential and integrated equation models.

Main Methods:

  • Models are defined by parameters rather than FORTRAN code.
  • Differential equation models utilize rate constants (zero-order, first-order, Michaelis-Menten).

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  • Integrated equation models incorporate baseline, exponential terms, or the Hill equation's Emax function.
  • Dose-concentration translation uses a reciprocal volume parameter.
  • Time parameters allow specification of dose, infusion, and lag times.
  • Users can select from various differential equation solvers and fitting algorithms.

    • Main Results:

    • BOOMER allows specification of complex models through parameter selection.
    • The program facilitates translation of mass units to concentration units.
    • Flexible parameterization supports diverse model structures and time-dependent events.

    Conclusions:

    • BOOMER offers a significant improvement over previous non-linear regression tools.
    • Its parameter-driven approach simplifies the development of sophisticated pharmacokinetic models.
    • The software enhances accessibility and efficiency for pharmacokinetic and pharmacodynamic analyses.