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Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis

Yongbin Lu1, Zhiyuan Cheng2, Yaxue Zhao1

  • 1Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, PR China.

Atherosclerosis
|November 6, 2016
PubMed

Insights

Long-term statin use effectively lowers blood lipids and reduces coronary heart disease (CHD) mortality and all-cause mortality. However, statins may increase the risk of muscle and kidney diseases.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Coronary heart disease (CHD) remains a leading cause of mortality worldwide.
  • Long-term management strategies for CHD are crucial for improving patient outcomes.
  • Statins are widely prescribed lipid-lowering medications with established cardiovascular benefits.

Purpose of the Study:

  • To evaluate the long-term efficacy of statin therapy in managing coronary heart disease.
  • To assess the safety profile and adverse events associated with prolonged statin use.
  • To compare the effectiveness of different statins in reducing mortality and improving lipid profiles.

Main Methods:

  • A systematic review and Bayesian network meta-analysis were conducted.
  • Efficacy outcomes included changes in blood lipids, CHD mortality, and all-cause mortality.
  • Safety outcomes focused on the incidence of adverse events, including muscle and kidney diseases.

Main Results:

  • Statin treatment significantly reduced blood lipid levels, with high-dose atorvastatin showing the most pronounced effect.
  • Statins demonstrated a significant reduction in the risk of CHD mortality (OR 0.69) and all-cause mortality (OR 0.84).
  • Atorvastatin and fluvastatin were identified as particularly effective in reducing both CHD and all-cause mortality, while statins were associated with an increased risk of muscle and kidney diseases.

Conclusions:

  • Long-term statin therapy is effective in reducing blood lipids and mortality in patients with CHD.
  • Specific statins, such as atorvastatin and fluvastatin, offer superior benefits in mortality reduction.
  • Clinicians should carefully weigh the benefits of statins against the potential risks of adverse events like muscle and kidney damage.
Abstract

Keywords:
Blood-lipidCHDEfficacyMortalitySafetyStatin

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