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Updated: Aug 14, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
[A ten years' experience with 613 mitral valve replacements]
Abstract:
This study was performed to assess the effect of factors on early and late mortality of isolated MVR in 613 patients. The tilting disc valve was used in 480 and the porcine xenograft bioprosthesis in 133 patients between Sep. 1978 and Nov. 1987. The overall early mortality rate was 4.89%. A comparative analysis showed that five factors (emergency operation, biventricular hypertrophy with serain, pulmonary hypertension, function class IV, and reoperation) significantly increased the early mortality rates (P less than 0.01). A 10-year follow-up study showed that the late mortality rate was significantly higher in patients with mitral insufficiency, function class IV and left ventricular hypertrophy with strain (P less than 0.01). The authors emphasize that the MVR must be performed early before the factors affecting the operative outcome are fully developed. Successive treatment with digitalis and/or diuretics should be continued in early postoperative period for 6-12 months to improve the cardiac function. Owing to the well-known durability of the bioprosthesis the authors prefer the use of mechanical valve.
Insights
Early mitral valve replacement (MVR) is crucial to reduce mortality. Factors like emergency surgery and advanced heart conditions significantly increase early and late death risks after MVR.
Area of Science:
- Cardiovascular Surgery
- Cardiac Valve Disease
- Surgical Outcomes Research
Context:
- Isolated mitral valve replacement (MVR) is a common cardiac procedure.
- Understanding factors influencing mortality is vital for patient management.
- This study analyzes outcomes in 613 patients undergoing MVR.
Purpose:
- To identify risk factors associated with early and late mortality after isolated mitral valve replacement.
- To compare outcomes between mechanical tilting disc valves and porcine xenograft bioprostheses.
- To provide recommendations for optimizing MVR surgical timing and postoperative care.
Summary:
- The study evaluated 613 patients undergoing isolated mitral valve replacement (MVR) between 1978 and 1987.
- Early mortality was 4.89%, with emergency operations, biventricular hypertrophy, pulmonary hypertension, functional class IV, and reoperation identified as significant risk factors (P < 0.01).
- Late mortality was higher in patients with mitral insufficiency, functional class IV, and left ventricular hypertrophy with strain (P < 0.01).
Impact:
- Recommends early MVR before significant comorbidities develop to improve surgical outcomes.
- Suggests continued digitalis and/or diuretic therapy for 6-12 months postoperatively to enhance cardiac function.
- Highlights a preference for mechanical valves due to bioprosthesis durability concerns.
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Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation III: Medical Management
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Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management

