Related Experiment Video
Updated: Mar 13, 2026

Place and Response Learning in the Open-field Tower Maze
Published on: October 28, 2015
Identifying Treatment Effect Modifiers in the STarT Back Trial: A Secondary Analysis.
Jason M Beneciuk1, Jonathan C Hill2, Paul Campbell2
1Department of Physical Therapy, University of Florida, Gainesville, Florida; Brooks Rehabilitation-College of Public Health and Health Professions (University of Florida) Research Collaboration, University of Florida, Gainesville, Florida.
Socioeconomic status influences low back pain (LBP) treatment outcomes. High socioeconomic status patients receiving stratified care had better results than low socioeconomic status patients receiving standard care, suggesting targeted LBP treatment is key.
Area of Science:
- Low back pain (LBP) research
- Clinical trial analysis
- Health services research
Background:
- Low back pain (LBP) management is a priority.
- Prognostic stratified care shows effectiveness for LBP.
- Patient characteristics influencing treatment response require exploration.
Purpose of the Study:
- To identify patient characteristics that modify treatment effects in the STarT Back trial.
- To explore socioeconomic status, education, and pain medication use as potential effect modifiers.
Main Methods:
- Secondary analysis of the STarT Back trial data (n=688).
- Treatment response defined by Roland-Morris Disability Questionnaire score (≥7).
- Logistic regression with interaction terms used to evaluate effect modification.
Main Results:
- Socioeconomic status (SES) was a significant effect modifier (OR=1.71, P=0.028).
- High SES patients on stratified care had 2.5 times lower odds of poor outcomes compared to low SES patients on best care (OR=0.40, P=0.006).
- Education and pain medication count showed weaker evidence of effect modification.
Conclusions:
- Socioeconomic status is a key factor influencing prognostic stratified care outcomes for LBP.
- Education and pain medication use may also modify treatment response.
- Findings highlight the need for personalized approaches in LBP management.
More Related Videos
07:01Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
Published on: September 20, 2020
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Related Concept Videos
Blinding
Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs
Blind Procedures
Therapeutic Drug Monitoring: Affecting Factors