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Updated: Mar 13, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Direct Thrombin Inhibitor for LVAD Thrombosis: A Closer Look
Jessica Rimsans1, Katelyn W Sylvester1, Jean M Connors2
11 Department of Pharmacy Services, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Abstract:
Available options for the treatment of advanced heart failure have expanded to include the use of mechanical circulatory assist devices to improve quality of life in those both eligible and ineligible for heart transplant. Although there have been significant advancements in device technologies, anticoagulation protocols, and multidisciplinary team management, bleeding and thrombosis are the most common adverse effects. Management strategies for pump thrombosis and their outcomes vary considerably among mechanical circulatory support centers and include intensification of antithrombotic therapy (medical) and device exchange (surgical). We describe a successful case of medical therapy for pump thrombosis with bivalirudin monotherapy.
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