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Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression
Vishal Bali1, Satabdi Chatterjee1, Michael L Johnson1
1Department of Pharmaceutical Health Outcomes and Policy, Texas Medical Center, College of Pharmacy, University of Houston, Houston, TX, USA.
Objective:
This study evaluated the risk of cognitive decline associated with paroxetine use in elderly nursing home patients with depression.
Methods:
A retrospective cohort study was conducted using the 2007 to 2010 Medicare Part D claims and minimum data set (MDS) data involving new users of paroxetine and other selective serotonin reuptake inhibitors (SSRIs). The primary outcome was MDS Cognition Scale. The repeated-measures mixed model was used to examine the effect of paroxetine on cognition after controlling for other factors.
Results:
The baseline MDS Cognition Scale measures for paroxetine (n = 63) and other SSRI users (n =1018) were 2.02 (±1.85) and 2.50 (±2.39), respectively. The repeated-measures mixed model did not find statistically significant difference in cognition with the use of paroxetine (β = 0.02, 95% CI: -0.16 to 0.21]) when compared to other SSRIs.
Conclusions:
There was no differential effect of paroxetine on cognition when compared to other SSRIs.
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