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Updated: Mar 13, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
Published on: December 11, 2017
Complete Resolution of Wegener's Granulomatosis Lung Granuloma After Aortic Root Replacement
Sarah-Jayne Edmondson1, Saina Attaran1, Ulrich P Rosendahl1
1Royal Brompton Hospital NHS Foundation Trust, Department of Cardiothoracic Surgery, London, UK.
Abstract:
Wegner's granulomatosis (WG) is an autoimmune systemic vasculitis that results in necrotizing granulomas. We report a WG patient with a lung granuloma and aortic root dilatation, who underwent aortic root replacement on cardiopulmonary bypass (CPB). Intraoperatively, the patient suffered an aortic dissection, which was repaired immediately under deep hypothermic circulatory arrest (DHCA). Follow-up imaging showed complete granuloma resolution, despite absence of immunosuppressive therapy. Immune stimulation following CPB is well described; here, the opposite was observed and DHCA effects are discussed.
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