Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Morphologies01:29

Microbial Morphologies

4.6K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The 2019 FIGO classification for cervical carcinoma-what's new?]

Der Pathologe·2019
Same author

[Un- and dedifferentiated endometrial carcinoma : A rare entity with a wide range of differential diagnosis].

Der Pathologe·2019
Same author

[TNM classification of gynecologic malignancies : What remains to be done beyond 2017?]

Der Pathologe·2019
Same author

[Histopathology and clinical aspects of extrauterine pregnancy].

Der Pathologe·2018
Same author

[Nomenclature of squamous cell precursor lesions of the lower female genital tract : Current aspects].

Der Pathologe·2016
Same author

[Grading of gynecological tumors : Current aspects].

Der Pathologe·2016

Related Experiment Video

Updated: Mar 13, 2026

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

13.0K

[Cervical cancer : Update on morphology].

L-C Horn1, C E Brambs2, R Handzel3

  • 1Abteilung Mamma-, Gynäko- und Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Liebigstraße 26, 04103, Leipzig, Deutschland. hornl@medizin.uni-leipzig.de.

Der Pathologe
|October 28, 2016
PubMed
Summary

The 2014 World Health Organization classification distinguishes uterine cervical adenocarcinoma subtypes. The gastric subtype, linked to Peutz-Jeghers syndrome and poor prognosis, is not associated with human papillomavirus (HPV).

Keywords:
AdenocarcinomaBiomarkersGradingMolecular pathologyQuality indicators

More Related Videos

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.7K
Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

11.4K

Related Experiment Videos

Last Updated: Mar 13, 2026

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
08:09

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection

Published on: July 25, 2017

13.0K
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

13.7K
Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
06:57

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

11.4K

Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Cancer Research

Background:

  • The 2014 World Health Organization (WHO) classification details uterine cervical adenocarcinoma subtypes.
  • A recently identified gastric subtype shows no association with high-risk human papillomavirus (HPV).
  • This gastric subtype is linked to Peutz-Jeghers syndrome and has a poor prognosis, predominantly in women of Asian descent.

Purpose of the Study:

  • To review prognostic parameters for uterine cervical adenocarcinomas.
  • To discuss the relevance of invasion patterns and tumor size in grading and surgical planning.
  • To evaluate the current predictive and prognostic relevance of histological type, molecular parameters, and biomarkers.

Main Methods:

  • Review of the 2014 WHO classification of uterine cervical adenocarcinomas.
  • Analysis of histopathological parameters relevant for prognosis and treatment.
  • Evaluation of the predictive value of histological type, molecular markers, and biomarkers.

Main Results:

  • The gastric subtype of mucinous adenocarcinoma is associated with poor prognosis and not linked to HPV.
  • Deep stromal infiltration (>66% of cervical stroma) is a key feature of macroinvasive carcinomas.
  • Tumor size (e.g., ≤2 cm) may become a discriminator for less radical surgical planning.
  • Histological type alone lacks predictive or prognostic relevance for various treatment modalities.
  • Currently, molecular parameters and biomarkers hold no prognostic or predictive relevance.

Conclusions:

  • Histopathological parameters, particularly invasion patterns and tumor size, are crucial for prognostic assessment and treatment planning in uterine cervical adenocarcinomas.
  • The gastric subtype represents a distinct entity with unique clinical and pathological characteristics.
  • Further research may refine grading systems and treatment strategies based on these histopathological findings.