Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

17.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.6K
Mitochondrial Membranes01:45

Mitochondrial Membranes

2.2K
2.2K
Porin Insertion in the Outer Mitochondrial Membrane01:12

Porin Insertion in the Outer Mitochondrial Membrane

5.1K
Porins are beta-barrel proteins translocated to the mitochondrial outer membrane through the TOM complex into the intermembrane space. Porin precursors bind TIM chaperones within the intermembrane space and are guided to the Sorting and Assembly Machinery complex or SAM complex on the outer mitochondrial membrane.
Three models describe the assembly of porins by the SAM complex and their insertion into the outer membrane. Model 1 suggests that porins are assembled outside the SAM channel as the...
5.1K
Mitochondria01:37

Mitochondria

21.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.1K
Amyloid Fibrils03:03

Amyloid Fibrils

12.5K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.5K
Amyloid Fibrils03:03

Amyloid Fibrils

6.9K
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TOTAL MAXILLARY BEAK RECONSTRUCTION IN A SOLOMON'S COCKATOO (<i>CACATUA DUCORPSII</i>) BY USING A SKULL-ANCHORED TITANIUM MESH PLATE PROSTHESIS: A NOVEL SURGICAL APPROACH OVERCOMING KERATIN-DEPENDENT FIXATION LIMITATIONS-A CASE REPORT.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians·2026
Same author

Folate receptor 1 activation suppresses high glucose-induced amyloidogenesis in neurons via STAT3/Nrf2 pathway-dependent mitigation of mitochondrial oxidative stress.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Combined intra- and extracapsular stabilization for CCL rupture in a toy-breed dog: a case report.

Frontiers in veterinary science·2025
Same author

Outcomes of 87 small-breed dogs surgically treated for Chiari-like malformation and syringomyelia.

Veterinary surgery : VS·2025
Same author

Disarming Salmonella virulence with 32H-hilE anti-virulence bacteriophage.

Microbiological research·2025
Same author

Recovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol-induced neurodegeneration.

International journal of biological sciences·2025

Related Experiment Video

Updated: Mar 13, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

6.4K

Relationship Between β-Amyloid and Mitochondrial Dynamics.

Dah Ihm Kim1, Ki Hoon Lee1, Ji Young Oh2

  • 1Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, South Korea.

Cellular and Molecular Neurobiology
|October 22, 2016
PubMed
Summary

Mitochondrial dynamics, involving fission and fusion, are crucial for cellular energy. Disruptions in this balance are linked to Alzheimer's disease (AD) pathogenesis and neuronal death.

Keywords:
Alzheimer’s diseaseMitochondrial dynamicsMitochondrial dysfunctionOxidative stressβ-Amyloid (Aβ)

More Related Videos

Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

5.0K
Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

1.3K

Related Experiment Videos

Last Updated: Mar 13, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

6.4K
Author Spotlight: Decoding Mitochondrial Aging
08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

5.0K
Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)
06:41

Quantitative Analysis of Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Stabilization in a Neural Model of Alzheimer's Disease (AD)

Published on: January 10, 2025

1.3K

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Mitochondria are dynamic organelles whose morphology is regulated by fission and fusion.
  • Imbalances in mitochondrial dynamics disrupt energy production and increase reactive oxygen species, contributing to Alzheimer's disease (AD) pathophysiology.
  • Abnormal mitochondrial dynamics and function are implicated in neurodegeneration and neuronal cell death in AD.

Purpose of the Study:

  • To review current knowledge on signaling mechanisms regulating mitochondrial dynamics.
  • To explore the role of mitochondrial dynamics in neurodegenerative diseases, with a focus on AD.
  • To elucidate the machinery involved in mitochondrial dynamics.

Main Methods:

  • Literature review of signaling pathways and molecular mechanisms.
  • Analysis of studies linking mitochondrial dynamics to neurodegenerative processes.
  • Synthesis of current understanding of mitochondrial morphology regulation.

Main Results:

  • Mitochondrial dynamics are critical for maintaining mitochondrial function and cellular health.
  • Dysfunctional mitochondrial dynamics contribute significantly to Alzheimer's disease progression.
  • Several signaling pathways are proposed to regulate mitochondrial morphology, but the complete machinery remains unclear.

Conclusions:

  • Mitochondrial dynamics play a pivotal role in neuronal function and are implicated in Alzheimer's disease.
  • Understanding the signaling mechanisms of mitochondrial dynamics is essential for developing therapeutic strategies for AD.
  • Further research is needed to fully elucidate the molecular machinery governing mitochondrial dynamics.