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Increased intraglomerular thrombin formation in diabetic microangiopathy
1Second Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
Diabetes Research and Clinical Practice
|August 1, 1989
Summary
Diabetic patients show higher soluble fibrin monomer complexes (SFMC) in renal veins than arteries, indicating the kidney produces SFMC. Elevated SFMC may signal diabetic vascular complications.
Area of Science:
- Nephrology
- Diabetology
- Hematology
Background:
- Soluble fibrin monomer complexes (SFMC) are an indicator of thrombin activation.
- Diabetic vascular complications, including nephropathy and retinopathy, are significant health concerns.
Purpose of the Study:
- To investigate renal venous-arterial differences in plasma SFMC concentrations in diabetic patients.
- To determine if the kidney is a source of SFMC.
- To explore the potential role of SFMC in diabetic microangiopathy.
Main Methods:
- Simultaneous blood sampling from the renal artery and vein in 16 diabetic patients using the Seldinger method.
- Quantification of plasma SFMC concentrations.
Main Results:
- SFMC concentrations were consistently higher in renal vein plasma compared to renal artery plasma across all subjects.
- Markedly elevated venous-arterial SFMC differences were observed in patients with severe renal and retinal microangiopathy and hypertension.
- These findings suggest the kidney is a significant source of SFMC.
Conclusions:
- The kidney actively contributes to circulating SFMC levels.
- Elevated SFMC may be associated with the pathogenesis of diabetic vascular complications, such as glomerular and retinal microangiopathy.
- Plasma SFMC could serve as a valuable biomarker for assessing the severity of diabetic vascular complications.