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Updated: Mar 13, 2026
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
The histopathologic features of autoimmune progesterone dermatitis
Travis James1, Jessica Ghaferi2, Ann LaFond2
1Department of Dermatology, St. Joseph Mercy Hospital, Ypsilanti, MI, 48197, USA.
Background:
The histologic features of autoimmune progesterone dermatitis (APD) are generally non-specific and have been described only in brief case reports. We present a case of APD and review the literature with a focus on the histologic findings described.
Methods:
A review of the English literature on APD was performed using PubMed and MEDLINE.
Results:
A total of 39 patients, including our patient are included in this review. The most consistent histologic finding reported was a perivascular inflammatory infiltrate, being seen in 72% of cases. A non-specific or interstitial inflammatory infiltrate was described in 31% of the cases, with 41% having an eosinophilic component and 21% having a neutrophilic component mixed with the predominant lymphocytic infiltrate. Interface dermatitis was the second most common finding with 36% showing a mild to exaggerated interface dermatitis.
Conclusion:
Although histopathologic changes are non-specific, perivascular dermatitis with eosinophils and interface changes are common in APD.
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