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Rosai-Dorfman Disease.

B N Mahanta¹, T Goswami Mahanta²

¹Associate Professor Medicine.

The Journal of the Association of Physicians of India

|October 22, 2016

Summary

Rosai Dorfman Disease, a rare condition, caused recurrent neck swellings in a young male. The disease was diagnosed via fine-needle aspiration cytology and immunohistochemistry, and the patient improved with supportive care.

Area of Science:

Medical Pathology
Immunohistochemistry
Rare Diseases

Background:

Recurrent neck swellings can indicate various underlying pathologies.
Accurate diagnosis is crucial for effective patient management.

Observation:

A young male presented with recurrent cervical lymphadenopathy.
Initial investigations revealed elevated leukocyte count and non-caseating granulomas on ultrasound-guided biopsy.
Fine-needle aspiration cytology (FNAC) showed characteristic histiocytic and lymphophagocytic features.

Findings:

Immunohistochemistry confirmed histiocytic markers (CD68) and proliferation index (Ki-67).
CD25 expression was also noted on histiocytes.
The findings were consistent with a diagnosis of Rosai-Dorfman Disease.

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Implications:

This case highlights the diagnostic utility of FNAC and immunohistochemistry in Rosai-Dorfman Disease.
Supportive treatment alone may be sufficient for managing this rare condition.
Further research into optimal therapeutic strategies for Rosai-Dorfman Disease is warranted.