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Updated: Mar 13, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
Hyperpolarized Multi-Metal 13C-Sensors for Magnetic Resonance Imaging
Anurag Mishra1, Giorgio Pariani1, Thomas Oerther2
1Institute for Biological and Medical Imaging & Institute of Developmental Genetics, Helmholtz Zentrum München , D-85764, Neuherberg, Germany.
Abstract:
We introduce hyperpolarizable 13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable 13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.
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