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Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
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Antimicrobial metal-based thiophene derived compounds.

Shakeela Yasmeen1, Sajjad Hussain Sumrra2, Muhammad Safwan Akram3

  • 1a Institute of Chemical Sciences , Bahauddin Zakariya University , Multan , Pakistan.

Journal of Enzyme Inhibition and Medicinal Chemistry
|October 22, 2016
PubMed
Summary
This summary is machine-generated.

Novel thiophene Schiff bases and their metal complexes show significant antibacterial and antifungal activity. Chelation with transition metals like cobalt and copper enhanced the antimicrobial efficacy of these compounds.

Keywords:
Acetyl thiopheneantimicrobial activitydiamminesmetal(II) chelatestridentate ligands

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Area of Science:

  • Coordination Chemistry
  • Medicinal Chemistry
  • Organic Synthesis

Background:

  • Schiff bases are versatile organic compounds with diverse applications.
  • Thiophene derivatives are known for their biological activities.
  • Transition metal complexes often exhibit enhanced pharmacological properties.

Purpose of the Study:

  • To synthesize novel thiophene-derived Schiff bases and their transition metal complexes.
  • To investigate the antimicrobial potential of these synthesized compounds.
  • To evaluate the effect of metal chelation on antimicrobial activity.

Main Methods:

  • Synthesis of Schiff base ligands and their metal complexes (Co(II), Cu(II), Zn(II), Ni(II)).
  • Characterization of synthesized compounds using spectroscopic techniques.
  • In vitro screening for antibacterial activity against six bacterial strains.
  • In vitro screening for antifungal activity against six fungal strains.

Main Results:

  • The synthesized Schiff bases exhibited potential antimicrobial activity.
  • Complexation with transition metals significantly enhanced the antibacterial and antifungal efficacy.
  • The tridentate nature of the ligands facilitated effective metal chelation.

Conclusions:

  • Thiophene-derived Schiff bases and their metal complexes are promising antimicrobial agents.
  • Metal chelation is an effective strategy to potentiate the antimicrobial activity of Schiff bases.
  • These compounds hold potential for the development of new antimicrobial therapies.