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Iohexol myelography in the horse
H M Burbidge1, N Kannegieter, L R Dickson
1Department of Veterinary Clinical Sciences, Massey University, Palmerston North, New Zealand.
Equine Veterinary Journal
|September 1, 1989
Summary
Iohexol provides diagnostic equine myelograms with minimal adverse effects. This non-ionic contrast agent shows less irritation compared to older agents, making it a safer option for horses.
Area of Science:
- Veterinary Medicine
- Radiology
- Pharmacology
Background:
- Myelography is crucial for diagnosing spinal cord issues in horses.
- Non-ionic contrast agents are preferred for reduced neurotoxicity.
- Previous agents like metrizamide and iopamidol have shown varying degrees of irritation.
Purpose of the Study:
- To evaluate the safety and efficacy of iohexol for equine myelography.
- To compare the irritant potential of iohexol with other contrast media in horses.
Main Methods:
- Horses underwent cervical myelography using iohexol at 300 and 350 mg iodine/ml concentrations.
- Cerebrospinal fluid (CSF) was analyzed for pathological changes (white blood cell count, specific gravity) post-procedure.
- Adverse effects such as extradural edema were noted.
Main Results:
- Diagnostic cervical myelograms were achieved with both iohexol concentrations.
- Minimal pathological changes were observed in CSF, including mild extradural edema.
- The increase in CSF white blood cells was significantly lower than reported for metrizamide and iopamidol.
Conclusions:
- Iohexol is a safe and effective contrast agent for equine myelography.
- Iohexol demonstrates a lower irritant profile in horses compared to metrizamide and iopamidol.
- Iohexol represents an improved option for veterinary spinal imaging.