Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

43.8K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.8K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

821
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
821
Disorder of Water Balance01:29

Disorder of Water Balance

2.7K
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
2.7K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.2K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
4.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.8K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.8K
Glucose Transporters01:27

Glucose Transporters

28.0K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
28.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resolution of childhood wheat allergy through evolution into WALDA? A case report.

Allergologie select·2026
Same author

Update of the evidence- and consensus-based S3 guideline on atopic dermatitis: Systemic therapy with biologics or Janus kinase inhibitors and specific aspects of systemic therapy in pregnancy and lactation.

Allergologie select·2026
Same author

PeakPASI as a marker of maximum psoriasis severity: a single-center, cross-sectional retrospective and questionnaire-based study.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

[Treatment of psoriasis as a systemic disease].

MMW Fortschritte der Medizin·2026
Same author

Demonstration of Gliadin Penetration into the Epidermis by Tape Stripping as Prerequisite for Percutaneous Sensitisation in Wheat Allergy.

International journal of molecular sciences·2026
Same author

Proliferation-associated protein 2G4 promotes keratinocyte proliferation and survival in psoriasis.

The British journal of dermatology·2026
Same journal

The different face of skin-rash induced by brentuximab vedotin.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Repositioning Non-Ablative Fractional Lasers - Molecular and Histological Insights from a scoping review.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Infusion-site reactions to foslevodopa/foscarbidopa in Parkinson's disease.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Tranexamic Acid-Soaked Intranasal Packing for Postoperative Bleeding After Nasal Interpolation Flap Repair.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Monoclonal gammopathy of dermatological significance: non-amyloid paraprotein deposits with light and heavy chains.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Papular epidermal nevus with "skyline" basal cell layer: Clinical clues from a three-member family.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.9K

Wells syndrome.

Andreas Benedikt Weins1,2, Tilo Biedermann2, Tina Weiss1

  • 1Department of Dermatology and Allergology, University Hospital Ulm, Ulm, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|October 22, 2016
PubMed
Summary
This summary is machine-generated.

Wells syndrome, or eosinophilic cellulitis, is a rare skin condition with varied symptoms. It presents as red, swollen patches on limbs that don't respond to antibiotics, requiring careful diagnosis and management.

More Related Videos

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K

Related Experiment Videos

Last Updated: Mar 13, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.9K
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
06:48

Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome

Published on: March 23, 2022

2.8K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

15.0K

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Wells syndrome, also known as eosinophilic cellulitis, is a rare eosinophilic dermatosis.
  • It presents with significant clinical variability, often mimicking bacterial infections like erysipelas or cellulitis.

Purpose of the Study:

  • To summarize the clinical presentation, diagnosis, potential etiology, and management of Wells syndrome.
  • To highlight the importance of recognizing this condition and its potential associations.

Main Methods:

  • Review of clinical and histological findings characteristic of Wells syndrome.
  • Discussion of proposed pathomechanisms involving Th2 cells and eosinophils.
  • Consideration of diagnostic challenges, including its nature as a diagnosis of exclusion.

Main Results:

  • Typical presentation includes infiltrated erythematous plaques on extremities, unresponsive to antibiotics.
  • Histological hallmark includes "flame figures" within dermal connective tissue.
  • Etiology is unresolved but linked to hypersensitivity responses involving eosinophils and Th2 cytokines like IL-5.

Conclusions:

  • Wells syndrome diagnosis requires clinical and histological evaluation, often after excluding other conditions.
  • Corticosteroids may benefit the chronic, recurrent nature of the disease.
  • Close patient follow-up is crucial due to observed transitions to hematological and oncological disorders.