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Wells-Syndrom.

Andreas Benedikt Weins1,2, Tilo Biedermann2, Tina Weiss1

  • 1Klinik für Dermatologie und Allergologie, Universitätsklinikum Ulm.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|October 22, 2016
PubMed
Summary
This summary is machine-generated.

Wells syndrome, or eosinophilic cellulitis, is a rare skin condition presenting with varied symptoms. Diagnosis requires clinical and histological evaluation, with corticosteroids often managing chronic forms.

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Wells syndrome, also known as eosinophilic cellulitis, is a rare dermatosis with diverse clinical presentations.
  • It often appears as inflammatory erythema or plaques on the extremities, initially resembling erysipelas but persisting under antimicrobial treatment.

Approach:

  • Diagnosis is based on exclusion, integrating clinical findings with characteristic histological features like flame figures, often requiring longitudinal assessment.
  • The etiology is unclear, but involvement of abnormal T-helper 2 (Th2) cells, IL-5 cytokine, and activated eosinophils suggests a hypersensitivity reaction.

Key Points:

  • Characterized by inflammatory erythema or plaques on extremities.
  • Histological findings include characteristic flame figures.
  • Diagnosis is made by exclusion, combining clinical and histological data.

Conclusions:

  • Chronic or recurrent forms of Wells syndrome respond favorably to glucocorticoids.
  • The condition is typically self-limiting with no residual effects.
  • Monitoring is recommended due to potential progression to hematologic malignancies.