Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

4.0K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
4.0K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

13.3K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
13.3K
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

2.7K
Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
2.7K
Conversion of Alcohols to Alkyl Halides02:48

Conversion of Alcohols to Alkyl Halides

8.8K
This lesson delves into the conversion of alcohols to corresponding alkyl halides and the mechanism of action for different reagents. Typically, the hydroxyl group is first protonated to convert it to a stable leaving group. Consequently, based on the starting alcohol, the mechanism undergoes either of the nucleophilic substitution routes, SN1 or SN2. Tertiary alkyl halides are made using the two-step SN1 mechanism that occurs via a carbocation intermediate, which is stabilized by...
8.8K
Heterogeneous Catalysis01:22

Heterogeneous Catalysis

69
Heterogeneous catalysis involves a catalyst in a different phase from the reactants. It is a process where the catalyst and the reactants are in distinct phases, typically solid and gas or liquid.Most heterogeneous catalysts are metals, metal oxides, or acids. The list includes transition metals like iron (Fe), cobalt (Co), nickel (Ni), palladium (Pd), platinum (Pt), chromium (Cr), manganese (Mn), tungsten (W), silver (Ag), and copper (Cu). These metals possess partially vacant d orbitals that...
69
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

Diels–Alder Reaction Forming Cyclic Products: Stereochemistry

5.2K
The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tetraphenylborate-based anionic metal-organic framework as an efficient single-ion conductor for solid-state sodium batteries.

Chemical science·2026
Same author

Polarity-Directed Synthesis of an Exfoliable 2D Polyoxometalate-Based Metal-Organic Framework for Noble Metal-Free Alkyne Transfer Semi-Hydrogenation.

Angewandte Chemie (International ed. in English)·2026
Same author

Dual-functionalized wood fibers with region-specific wettability for switchable oil/water separation systems.

Journal of hazardous materials·2026
Same author

Ultrathin Nanosheets Formed by Metal-Organic Cages Connected via Hydrogen Bonds.

Journal of the American Chemical Society·2025
Same author

Engineering Donor-Acceptor Arrangement in Perylene Diimide-Based Covalent Organic Frameworks for Enhanced Singlet Oxygen Photocatalysis.

Angewandte Chemie (International ed. in English)·2025
Same author

Anionic Metal-Organic Framework as an Ultrafast Single-Ion Conductor for Exceptional Performance Rechargeable Zinc Batteries.

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: Mar 13, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

7.9K

A Cr(salen)-based metal-organic framework as a versatile catalyst for efficient asymmetric transformations.

Qingchun Xia1, Yan Liu, Zijian Li

  • 1School of Chemistry and Chemical Engineering and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China. yongcui@sjtu.edu.cn liuy@sjtu.edu.cn.

Chemical Communications (Cambridge, England)
|November 2, 2016
PubMed
Summary

A porous chromium(III) salen-metal-organic framework (Cr(salen)-MOF) acts as a versatile heterogeneous catalyst. It efficiently catalyzes key asymmetric reactions, achieving high selectivity comparable to homogeneous catalysts.

More Related Videos

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
11:15

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin

Published on: July 23, 2016

10.7K
Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

49.4K

Related Experiment Videos

Last Updated: Mar 13, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

7.9K
HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
11:15

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin

Published on: July 23, 2016

10.7K
Synthesis and Characterization of Functionalized Metal-organic Frameworks
11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

49.4K

Area of Science:

  • Materials Science
  • Organic Chemistry
  • Catalysis

Background:

  • Homogeneous catalysts are widely used for asymmetric transformations.
  • Developing efficient heterogeneous catalysts remains a challenge.
  • Metal-organic frameworks (MOFs) offer tunable properties for catalysis.

Purpose of the Study:

  • To investigate the catalytic activity of a porous Cr(salen)-MOF.
  • To evaluate its performance in asymmetric reactions.
  • To compare its efficacy against homogeneous systems.

Main Methods:

  • Synthesis of a porous Cr(salen)-MOF.
  • Application of the MOF as a heterogeneous catalyst.
  • Analysis of reaction products for stereoselectivity.

Main Results:

  • The Cr(salen)-MOF demonstrated high efficiency as a heterogeneous catalyst.
  • It successfully catalyzed Nazarov cyclization, aminolysis, and Diels-Alder reactions.
  • Achieved comparable or superior diastereoselectivity and enantioselectivity versus homogeneous catalysts.

Conclusions:

  • Porous Cr(salen)-MOFs are effective heterogeneous catalysts for asymmetric synthesis.
  • This MOF offers a sustainable alternative to homogeneous catalysts.
  • Potential for broad application in complex organic molecule synthesis.