Related Experiment Video
Updated: Mar 13, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Deferiprone Enhances Temozolomide Cytotoxicity in Glioma Cells
George A Alexiou1, Paraskevi Gerogianni1, Evrysthenis Vartholomatos1
1a Neurosurgical Institute, University of Ioannina , Ioannina , Greece.
Abstract:
Glioblastoma is the most malignant primary brain tumor with a median survival of 15 months. Temozolomide (TMZ) is the standard of care for these patients. Iron chelators have been shown to have anti-tumor activity; however, deferiprone (DFP), an orally administered iron chelator, has not been previously evaluated in gliomas. In the present study, we found that combination treatment in glioma cells with TMZ and DFP significantly reduced cell viability, produced cell cycle arrest at G2/M phase, and enhanced apoptosis. TMZ and DFP might be a potent new combination treatment for glioblastoma.
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