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Identification of the ferroxidase centre in ferritin
D M Lawson1, A Treffry, P J Artymiuk
1Krebs Institute, Department of Molecular Biology and Biotechnology, The University, Sheffield, England.
FEBS Letters
|August 28, 1989
Abstract:
Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.