Related Experiment Video
Updated: Mar 13, 2026

04:29
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
29.8K
Internet-based cognitive behavioural therapy for subthreshold depression: a systematic review and meta-analysis
1School of Management, Beijing University of Chinese Medicine, #11 North Three-Ring Road East, Chaoyang District, Beijing, China, 100029.
BMC Psychiatry
|October 23, 2016
Summary
Internet-based cognitive behavioural treatments (iCBTs) show short-term effectiveness in reducing subthreshold depression symptoms. However, more research is needed to confirm the long-term benefits of iCBT for this condition.
Area of Science:
- Mental Health
- Psychiatry
- Digital Therapeutics
Background:
- Subthreshold depression significantly impacts well-being and functioning.
- It is a known predictor of major depressive disorder.
- Internet-based cognitive behavioural treatments (iCBTs) are utilized to alleviate these symptoms.
Purpose of the Study:
- To systematically review the evidence on the efficacy of iCBT programs for subthreshold depression.
- To assess the impact of iCBT on depressive symptoms in this population.
Main Methods:
- A systematic review and meta-analysis of randomized controlled trials (RCTs).
- Searched databases (Medline, PubMed, Web of Science, etc.) for articles from January 2005 to July 2016.
- Included RCTs comparing iCBT with control groups for subthreshold depression.
Main Results:
- Eight RCTs involving ten articles were analyzed.
- iCBT programs demonstrated superior short-term efficacy compared to non-active control groups (SMD = -0.28, CI [-0.42, -0.14]).
- Evidence regarding the long-term efficacy of iCBT remains insufficient.
Conclusions:
- iCBT interventions show significant short-term effectiveness for subthreshold depressive symptoms.
- The long-term efficacy of iCBT for subthreshold depression requires further investigation.
- This review highlights the potential of iCBT while underscoring the need for extended follow-up studies.

